In 12 seasons and 143 regular season games he scored 111 total touchdowns, accumulated 11,213 total yards, made seven Pro Bowls, and five all-NFL teams. In 1964, he had one of his best statistical seasons when he scored 20 touchdowns, helping to lead the Colts to a 12–2 regular-season record and a trip to the NFL Championship Game for the third time in seven seasons. Moore scored a touchdown in an NFL-record 18 consecutive appearances starting in 1963 and continuing through the entire 1964 season, ending in 1965. He also won Comeback Player of the Year Award in 1964. We split. He was voted by his fellow players as the Most Valuable Player, a remarkable award considering he played most of the season with complications from appendicitis, and gave credence to the claim that he was one of the toughest players in the NFL. Moore occasionally speaks to student groups about his experiences as a black football player during an era when, in the words of "There was never anybody ever closer than me and the guys that I played football with on that Baltimore team – on the field," Moore told the Sun. Moore was injured in 1962, a knee injury, and lost his starting job in 1963 from the knee injury.

In 1959, Moore had 47 receptions for 846 yards and six touchdowns as the Colts repeated as champions. One for all, all for one." In 12 seasons and 143 regular season games he scored 111 total touchdowns, accumulated 11,213 total yards, made seven Pro Bowls, and five all-NFL teams.

His race also came into question after his retirement in 1968 when he was not given a long-term contract with CBS Television, ending his attempt to be the first black sports broadcaster for CBS. His job with the state included traveling to middle and high schools, mixing and mingling with at-risk children, trying to keep them straight. It was race." "We were just like glue. He had 40 receptions for 687 yards and seven touchdowns in 1957, the first of five years in which he would have 40 or more catches.
In an era of pounding running games, Moore was a glimpse of things to come in the NFL, with a career average of 30 receptions per year out of the backfield.During his rookie season in 1956, Moore established himself as one of the most well rounded runners and receivers in the league, and won the NFL Rookie of the Year award. Moore retired from professional football after the 1967 season.

He attended Reading High School, where his speed on the field earned him the nickname “The Reading Rocket.” He was tagged with a number of other nicknames: "Moore leveraged his speed and ability into a college Moore’s achievements at Penn State did not go unnoticed by scouts from the NFL, and he was drafted by the Colts in the first round of 1956 with the ninth pick.Moore was both a great runner and receiver, lining up in the backfield as a halfback and split wide as a flanker, and was equally dangerous at both positions in the Colts' offense run by quarterback Johnny Unitas.